Granulation & Coating Technology Seminar

April 17-19, 2012

 

This three day seminar is held at Freund-Vector in Marion, Iowa and integrates classroom lecture and hands-on laboratory sessions to provide a comprehensive learning experience. There will be one full day of lectures and two days of hands-on laboratory sessions to provide the participants an overall understanding of solid dosage granulation and coating technologies.

 

A comparison overview of the fundamental concepts and properties of fluid bed granulation and coating, high shear wet granulation, roll compaction compression granulation and tablet pan coating techniques will be presented and demonstrated. This seminar is intended for all Pharmaceutical and Healthcare Scientists, Technologists, Operators, Supervisors and personnel involved in the development and processing of solid dosage granulations and coating processes.

 

Download Registration Form

 

COURSE OUTLINE

Granulation Technology Overview

• Roll Compaction – Compression Granulation
• High Shear – Wet Granulation
• Fluid Bed – Top Spray and Rotor Granulation

Coating Technology Overview

• Fluid Bed Coating Technologies:
  • Top Spray
  • Wurster Bottom Spray
  • Rotor Peripheral Spray
• Perforated Pan Coating Technology

Granulation and Coating Formulations, Excipients and Properties

• Granulation Formulation Strategies:
  • Selection of Excipients
  • Use of Binders, Filler, Glidants, Lubricants and Disintegrants
• Coating Material Function and Properties:
  • Basic Formulation Ingredients - Polymers, Plasticizers, Colorants and Solvents

Roll Compaction Compression Granulation Technology

• Applications
• Process Principles
• Formulation Issues
• Equipment Design
• Scale-Up and Optimization

High Shear Wet Granulation Technology

• Applications
• Process Principles
• Formulation Issues
• Equipment Design
• Scale-Up and Optimization

Top Spray Fluid Bed Granulation Technology

• Applications
• Process Principles
• Formulation Issues
• Equipment Design
• Scale-Up and Optimization

Bottom Spray Fluid Bed Coating Technology

• Applications
• Process Principles
• Formulation Issues
• Equipment Design
• Scale-Up and Optimization

Rotor Fluid Bed Spheronization Granulation and Coating Technology

• Applications
• Process Principles
• Formulation Issues
• Equipment Design
• Scale-Up and Optimization

Perforated Pan Tablet Coating Technology

• Applications
• Process Principles
• Formulation Issues – Aqueous, Solvent and Sugar Coatings
• Equipment Design
• Scale-Up and Optimization

LABORATORY HANDS-ON GRANULATION SESSIONS

Roll Compaction Compression Granulation

• Compression Granulation
• Dry Milling
• Process Optimization
• Product Analysis (PAT/QicPic Imaging)

High Shear Granulation

• High Shear Wet Granulation
• Wet Milling
• Fluid Bed Drying (NIR Moisture/LOD Analysis)
• Process Optimization

Fluid Bed Top Spray Granulation

• Fluid Bed Top Spray Granulation
• Proper Product Movement
• Proper Spray System Set-up
• Process Optimization
• Product Analysis (Screen Analysis/Stereo Microscope)

Fluid Bed Rotor Spheronization Granulation

• Rotor Spheronization Granulation
• Proper Spray System Set-up
• Process Optimization
• Product Analysis (QicPic/SEMs)

LABORATORY HANDS-ON COATING SESSIONS

Perforated Pan Tablet Coating

• Aqueous Tablet Coating
• Proper Product Movement
• Proper Spray System Set-Up
• Process Optimization
• Product Analysis (Camera Microscope)

Fluid Bed Bottom Spray Wurster Coating

• Proper Product Movement
• Proper Spray System Set-Up
• Process Optimization
• Product Analysis (SEMs/Screen Analysis/Stereo Microscope)

Fluid Bed Rotor Coating

• Proper Product Movement
• Proper Spray System Set-Up
• Powder Layering
• Polymer Coating

Process and Equipment Trouble Shooting

• Granulation Processes and Equipment
• Coating Processes and equipment
• Case Studies

EQUIPMENT FOR GRANULATION AND COATING HANDS-ON SESSIONS

Fluid Bed

• VFC-60M Top-Spray with a 220-liter volume
• VFC-60M Bottom Spray 18” Wurster
• VFC-15M Dryer with 20-Liter volume
• VFC-LAB 3 GXR-35 Rotor with a 15-liter volume

High Shear Granulator

• Model GMX-25 With A 25-Liter Volume

Roll Compactor

• Model TFC-LAB Micro With 5gr – 1 kg/hr Capacity
• Model TFC-220 With 20gr– 20 kg/hr Capacity

Perforated Pan Tablet Coater

• VHC-5811 with 55-Liter volume
• LDCS with 6-Liter volume

Seminar Hours

Tuesday ------- 8:00 AM – 5:30 PM

Wednesday ---- 8:30 AM – 5:30 PM

Thursday ------- 8:30 AM – 3:30 PM

 

Enrollment Information

Opening January 18, 2011

 

Contact Information

For questions or additional information please contact: Steve Kray (319) 377-8263 x 260 or email steve.kray@freund-vector.com.