Spray drying is a method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas. Applications of Spray Drying include enhanced solubility and bioavailability of API, encapsulation, powders for inhalation and aseptic production. These spray dying applications produce Amorphous Spray Dried Dispersions, Nano composites, Aseptic products and excipients for food and pharmaceutical industries. Freund-Vector’s CPL-2 offers Amorphous Spray Dried Dispersions.
Amorphous Spray Dried Dispersions
Solid dispersion is defined as the dispersion of one or more active ingredients in an inert excipient or matrix (carrier), where the active ingredients could exist in finely crystalline, solubilized or amorphous state. (Sareen et al., 2012; Kapoor et al.,2012). Spray drying of API and carrier polymer which are dissolved in a common solvent, leads to the formation of homogeneous, stable dispersion of amorphous drug molecularly dispersed in polymer matrix.
The illustration below portrays the Freund-Vector Amorphous Spray Dried Dispersion process.
CPL-2 GMP Laboratory / Development Spray Dryer
The new Freund-Vector CPL-2 GMP laboratory spray dryer introduces a new dimension to drug development and preparation of amorphous spray dried dispersions. Below are some unique equipment features:
- Robust stainless-steel construction
- Cyclone and bag differential pressure indicators
- Closed and open loops systems
- Solvent evaporation capacity 3 kg/hr (at inlet temperature of 140֯ C and outlet temperature of 70 ֯ C)
- Spray method- 2 Fluid nozzle (gas/liquid)
If interested in learning more about the CPL-2 GMP Spray Drying System, visit us at AAPS, booth #1827. Additionally, you can visit Freund-Vector’s website by clicking here. Looking forward to meeting with you and discussing how Freund-Vector can assist with your spray drying process and equipment needs.