Freund-Vector’s Continuous Manufacturing Posters at AAPS 2018

AAPS PharmSci 360 will be conducting their annual meeting, November 4-7, 2018 in Washington, DC.  Thousands of scientific posters featuring the latest, most innovative research in the pharmaceutical field will be available for review and discussion.  Freund-Vector will be featuring two posters on Continuous Manufacturing and the Granuformer®. You can view the Granuformer® process by clicking on this link.

Using Continuous Granulation to Make Robust and High Drug Load APAP Granules” will be presented 11:30-12:30 on Monday, November 5, 2018 by Mr. Tim Smith, Freund-Vector’s Senior Process Development Scientist.  This study explored the advantages of continuous granulation by twin screw technology on Freund Vector’s Granuformer® (Gf-215) to make high load acetaminophen (APAP) granules and studied the effect of polymer choice and process parameters in making robust granules.

  • Timothy J. Smith – Senior Process Development Scientist, Freund-Vector Corporation (Role: Presenting Author;Co-Author)
  • Prachi Shah – Process Development Scientist, Freund-Vector Corporation (Role: Main Author;Primary/Principal Investigator)
  • Aaron Boesen – Associate Process Development Scientist, Freund-Vector Corporation (Role: Co-Author)
  • Amol Batra – Staff Scientist, Ashland Specialty Ingredients (Role: Co-Author)
  • Qiangnan Zhang – Research Assistant, Temple University (Role: Co-Author)
  • Thomas Dürig, PhD – Senior Director, Ashland Specialty Ingredients (Role: Co-Author)
  • Yunxia Bi, Ph. D. – Technical Director, Ashland Specialty Ingredients (Role: Co-Author)

Optimization of Controlled Release Granule Properties by Screw Design in a Continuous Granulation System” will be presented 12:30-13:30 on Monday, November 5, 2018 by Mr. Tim Smith, Freund-Vector’s Senior Process Development Scientist.  The objective of this study was to evaluate the performance of different barrel and screw designs of a novel continuous granulation system on the granule properties of a hydroxypropyl methylcellulose (HMPC) based formulation.

  • Timothy J. Smith – Senior Process Development Scientist, Freund-Vector Corporation (Role: Presenting Author;Main Author;Primary/Principal Investigator)
  • Aaron Boesen – Associate Process Development Scientist, Freund-Vector Corporation (Role: Co-Author)
  • Ryan Crawford – Process Development Scientist, Freund-Vector Corporation (Role: Co-Author)
  • Kevin O’Donnell, Ph. D. – R&D Manager, The Dow Chemical Company (Role: Co-Author)

We look forward to discussing these technical posters with you during AAPS PharmSci 360 .   Please visit booth 1827 and talk to Ryan and Don about your continuous manufacturing requirements.

Granuformer® (GF-215)

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