Utilization of Starch Micro-Spheres as a Core Material for Dry Powder Layering of an API to Facilitate High API Loading in Particles Below 250 Microns

A starch microsphere was used as a core material in a dry powder layering process where an 80% Active Pharmaceutical Ingredient (API) content was required in a particle with a finished size below 250 microns. Size, shape, efficiency, process and content analysis of the finished coated particles showed that the starch microspheres were successfully used as a core material to create high API loaded particles under 250 microns in size.

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