To develop a novel process for applying methylmethacrylates (MMA) to multi-particulates using a rotor processor.

To develop a method for quickly and efficiently coating dry polymer onto beads using a rotor processor without the use of organic solvents.

To compare two methods for applying a sustained release polymer to acetaminophen beads and identify processing time, efficiency, solvent usage and dissolution results.

This study compared two processes used for the rapid production of high active content spherical beads: 1. Spherical Granulation without the use of a core particle, and 2. Dry Powder Layering, utilizing a core particle. Both approaches use a minimum of a simple binder solution to show the application efficiency, size uniformity, content uniformity and total process time to manufacture spherical beads suitable for coating for modified release.

To compare two processes, an established Wurster coating process for producing 100 – 300 micron Omeprazole coated beads and a Novel Rotor process for producing 100-300 micron Omeprazole coated beads to determine if advantages were present in either approach.

The development of a powder coating methodology including the utilization of a new type of fluidized bed apparatus is reported. Several different polymer systems were tried and
compared to solvent-based techniques using acetaminophen as a model drug. Process parameters are described and the performance of the polymer coating system relative to solvent based coating system is compared.

To evaluate the appropriateness of various PAT tools for characterizing particles at the beginning and end of a granulation/spheronization process.